(1) 新型给药系统研究
(2) 物理药剂学
(3) 微粒制剂研发与产业化

1、科研项目
（1）国家自然科学基金委员会，面上项目，81773908，基于活性氧的黄芩素光热化疗同步递药系统研究，2018-01-01 至 2021-12-31，60万元，已结题，主持
（2）国家自然科学基金委员会，面上项目，81073055，基于甘草次酸受体主动靶向肝实质细胞的中药脂质体研究，2011-01-01 至 2013-12-30，33万元，已结题，主持
（3）十二五中重大新药专项，2012ZX09102112，中药一类抗呼吸道病毒新药黄芩素片的临床前研究，2012-01-01 至 2015-12-31，350万元，已结题，主持
（5）江苏省科技厅，江苏省纳米药物制备与生物学评价公共技术服务中心，2018-01 至2021-12，50万元，已结题，主持
（5）江苏省科技厅，江苏省纳米药物制备与生物学评价公共技术服务中心，2022-01至2025-12，50万元，主持
（6）江苏省科技厅，省社会发展项目，BE2010725 黄芩片的研制 江2010-01至2012-12，20万元，已结题，主持

1.Chen M.; Qiao Y.Y.; Cao J.; Ta L.; Ci T.Y. *; Ke X. * Biomimetic doxorubicin/ginsenoside co-loading nanosystem for chemoimmunotherapy of acute myeloid leukemia. J Nanobiotechnology. 2022;20:273-83 (IF: 9.429)
2.Dai,J.L.; Chen,M.; Xu,D.M.; Li,H.J.; Qiao,Y.Y.; Ke, X.* . Ci, T.Y.*  Self-assembly delivery system based on small-molecule camptothecin prodrug for treatment of colorectal carcinoma. Nanomedicine. 2021;16:355-72. (IF: ??)
3.Wu H.; Lou Y.; Xu D.M.; Ke X. *; Ci T.Y. * Low molecular weight heparin modified bone targeting liposomes for orthotopic osteosarcoma and breast cancer bone metastatic tumors.Int J Bio Macromol.2020;164:2583-97. (IF: 5.162)
4.Xia, Y.L.; Yuan, M.; Chen,M.; Li,J.; Ci, T.Y.*; Ke, X.* Liquid jet breakup: A new method for the preparation of poly lactic-co-glycolic acid microspheres.Eur J Pharm Biopharm.2019;137:140-7.(IF: 3.383)
5.Cao D.L.G.;Zhang X.X.; MD., Akabar; Luo,Y.; Wu H.; Ke X.*; Ci T.Y.* Liposomal doxorubicin loaded PLGA-PEG-PLGA based thermogel for sustained local drug delivery for the treatment of breast cancer. Artif Cells Nanomed Biotechnol. 2019;47:181-91.(IF: 4.462)
6.Sun H.F.; Cao D.L.G.; Liu Y.H.; Wang H.;Ke X.*; Ci T.Y.* Low molecular weight heparin based reduction sensitive nanoparticles for antitumor and anti-metastasis of orthotopic breast cancer. Biomater Sci, 2018;6:2172-88. (IF: 5.83)
7.Sun H.F.; Cao D.L.G.; Wu H; Liu H.; Ke X.*; Ci T.Y.* Development of low molecular weight heparin based nanoparticles for metastatic breast cancer therapy.Int J Bio Macromol.. 2018;112:343-55.(IF:4.11)
8.Ci,T.Y.; Luo Y.; Bao, Y.Y.; Hou, Y.T.; Wu, H.; Sun, H.F.; Cao, D.L.G; Ke X.* Development and anti-Candida evaluation of the vaginal delivery system of amphotericin B nanosuspension loaded thermogel. J Drug Target. 2018,26:829-39. (IF: 3.068)
9.Chen, Y.; Li, H.H; Deng, Y.Y.; Sun, H.F.;Ke X.*; Ci T.Y.* Near-infrared light triggered drug delivery system for higher efficacy of combined chemo-photothermal treatment. Acta Biomater.2017;51:374-92.(IF: 6.01)
10.Hu D.R.; Mezghrani Omar; Zhang L.; Chen,Y.; Ke X.*; Ci T.Y.* GE11 peptide functionalized and reduction responsive hyaluronic acid-based self-assembled nanoparticles induced higher efficiency of doxorubicin for breast carcinoma therapy. Int J Nanomed. 2016;11:5125-47.(IF: 4.32)