(1) 药物质量控制关键技术
(2) 大分子药物分析

1、科研项目
主持国家自然科学基金1项、中央高校科研专项基金2项；参与十三五国家重点研发计划、十二五国家重大新药创制专项、江苏省自然科学基金2项。
主持和参与企业委托项目40余项。

1.Yang, T., Yue, G., Ge, Y., Zhang, Y., Xu, P., Wang, Y., Li, B.*, & Di, B.* (2022). SCH 23390 inhibits the acquisition of nitrous oxide-induced conditioned place preference and the changes in ERK phosphorylation expression in nucleus accumbens of mice. Neuroscience letters, 781, 136674. 
2.Abdulbagi, M., Wang, L., Siddig, O., Di, B.*, & Li, B.* (2021). D-Amino Acids and D-Amino Acid-Containing Peptides: Potential Disease Biomarkers and Therapeutic Targets?. Biomolecules, 11(11), 1716. 
3.Tan, B., Zhang, X., Quan, X., Zheng, G., Li, X., Zhao, L.*, Li, W.*, & Li, B.* (2020). Design, synthesis and biological activity evaluation of novel 4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl) oxy) pyridine-2-yl) amino derivatives as potent transforming growth factor-β (TGF-β) type I receptor inhibitors. Bioorganic & medicinal chemistry letters, 30(16), 127339. 
4.Wang, M., Niu, A., Gong, Z., Xu, Z., Li, L., Li, B.*, & Wang, J.* (2020). PEG-amino acid-przewaquinone a conjugations: Synthesis, physicochemical properties and protective effect in a rat model of brain ischemia-reperfusion. Bioorganic & medicinal chemistry letters, 30(1), 126780. 
5.Li, Z., Zhang, Z., Chen, Y., Tang, S., Lin, T., Huang, J., Li, B.*, & Jiang, C.* (2019). Design, synthesis and evaluation of d-amino acid-containing peptidomimetics targeting the polo-box domain of polo-like kinase 1. Bioorganic chemistry, 85, 534–540. 
6.Xu, N., Shanbhag, A. G., Li, B., Angkuratipakorn, T., & Decker, E. A. (2019). Impact of Phospholipid-Tocopherol Combinations and Enzyme-Modified Lecithin on the Oxidative Stability of Bulk Oil. Journal of agricultural and food chemistry, 67(28), 7954–7960. 
7.Phil, L., Naveed, M., Mohammad, I. S., Bo, L.*, & Bin, D.* (2018). Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 102, 438–451. 
8.Yang, Y., Lian, Y., Zhong, P., Wang, D., Di, B.*, & Li, B.* (2018). Characterization and quantitative analysis of related substances in Coenzyme A by HPLC and LC-MS/MS. Journal of pharmaceutical and biomedical analysis, 150, 220–232. 
9.Li, B., Zhang, J., Bu, F., & Xia, W.* (2013). Determination of chitosan with a modified acid hydrolysis and HPLC method. Carbohydrate research, 366, 50–54. 
10.Li, B., Zhang, J., Dai, F., & Xia, W.* (2012). Purification of Chitosan by Using Sol-gel Immobilized Pepsin Deproteinization, Carbohydrate Polymers, 88, 206-212.