(1) 蛋白质分析新材料和新方法研究
(2) 组学技术在疾病和毒品成瘾机制中的应用

1、科研项目
（1）国家自然科学基金委员会，面上项目，81773667，基于IDO1介导的炎癌转化“代谢-免疫”交互网络探讨三七总皂苷的物质基础和作用机制，2022-01-01 至 2025-12-31，55万元，在研，主持
（2）江苏省自然科学基金面上基金项目，BK20141356，基于LC-MS/MS非标记定量法对metadherin作为治疗人慢性粒细胞白血病耐药靶点相关机制研究，2014-07至2017-06，10万元，已结题，主持
（3）国家自然科学基金，青年基金，81202500，基于 LC-MS/MS非标记定量法对大黄素抑制人慢性粒细胞白血病细胞耐药作用机制研究，2013-01至2015-12，23万元，已结题，主持

1.Gao, L.; Tao, J.; Qi, L.K. ; Jiang, X.Y. ; Shi, H.F.; Liu, Y.H.; Di, B.*; Wang, Y.J.* ; Yan, F.* Synthesis of a metal oxide affinity chromatography magnetic mesoporous nanomaterial and development of a one-step selective phosphopeptide enrichment strategy for analysis of phosphorylated proteins. Anal Chim Acta, 2022, 1195: 339430. (IF: 6.911)
2.Qi, L.K.; Dong, T.; Jiang, X.Y.; Li, J.J.; Di, B.*; Yan, F*. Preparation of polydopamine-functionalized mesoporous silica-coated core/shell magnetic nanocomposite for efficiently extracting five amphetamine-type stimulants from wastewater followed by UPLC-MS/MS determination. J Hazard Mater, 2022, 426: 128082. (IF: 14.224)
3.Qi, L.K. ; Jiang, X.Y.; Wu, N. ; Li, J.J. ; Di, B. *; Yan, F.* Synthesis of a novel polydopamine and C18 dual-functionalized magnetic core-shell mesoporous nanocomposite for enrichment and analysis of widely abused illegal drugs in urine samples on site and in the laboratory. J Pharmaceut Biomed, 2022，212：114556 (IF: 3.935)
4.Li, X.M.; Yuan, D.Y.; Liu, Y.H.; Zhu, L.; Qin, H.K.; Yang, Y.B.; Li, Y. ; Yan, F.*; Wang, Y.J.* Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation. Chin J Nat Medicines， 2022, 20, 258 (IF: 3.887)
5.Yan F.; Liu G.; Chen T.; Fu X.; Niu M.M.* Structure Based Virtual Screening and Biological Evaluation of Peptide Inhibitors for Polo-Box Domain. Molecules, 2019, 25, 107 (IF: 4.411)
6.Yang, D.S.; Ding, X.Y.; Min, H.P.; Li, B.; Su, M.X.; Niu, M.M.; Di, B.*; Yan, F.* Design and synthesis of an immobilized metal affinity chromatography and metal oxide affinity chromatography hybrid material for improved phosphopeptide enrichment. Journal of Chromatography A, 2017, 1505: 56 (IF: 3.716)