(1) 新型细菌免疫机制的挖掘和应用
(2) 蛋白质生物合成机器的工作机制研究

国家自然基金面上项目，32271330，V-K型CRISPR-associated transposase系统催化DNA定点插入的分子机制研究，2023-01至2026-12，54万元，在研，主持
国家自然科学基金青年项目，32000889，脊椎动物ThrRS对tRNA(Thr)错误丙氨酰化的校正作用及其分子机理研究，2021-01至2023-12，24万元，在研，主持

1. Guo, L.J.; Huang P.P.; Li, Z.X.; Shin, Y.C.; Yan, P.R.; Lu, M.L.; Chen, M.R.*; Xiao, Y.B.* Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nature Chemical Biology, 2023. (IF: 16.284)
2. Yuan, C. ; Li, Z.H. Luo, X.Y.; Huang, P.P.; Guo, L.J.; Lu, M.L; Xia, J.; Xiao, Y.B.*; Zhou, X.L.*; Chen, M.R.* Mammalian trans-editing factor ProX is able to deacylate tRNAThr mischarged with alanine. International Journal of Biological Macromolecules, 2023;253:127121 (IF: 8.025)
3. Zeng, T.; Yin, J.; Liu, Z.W.; Li, Z.X.; Zhang, Y.; Lv, Y.; Lu, M.; Luo, M.; Chen, M.R.*; Xiao, Y.B.* Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system. Cell Reports, 2023; 42:112698. (IF: 9.995)
4.Yang, H.; Yan, R.X.; Li, Y.; Lu, Z.X.; Bie, X.M.; Zhao, H.Z.; Lu, F.X.*; Chen, M.R.* Structure–Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification. Journal of Agricultural and Food Chemistry, 2022; 70: 6764-6774. (IF: 5.895)
5. Gao, H.; Niu, J.F.; Yang, H.; Lu, Z.X.; Zhou, L.B.; Meng, F.Q.; Lu, F.X.*; Chen, M.R.* Epimerization of deoxynivalenol by the Devosia strain A6-243 assisted by pyrroloquinoline quinone. Toxins, 2021;14, 16. (IF: 5.075)
6. Niu, J.F.; Meng, F.Q.; Zhou, Y.W.; Zhang, C.; Lu, Z.X.; Lu, F.X.*; Chen, M.R.* Non-classical secretion of a type I L-asparaginase in Bacillus subtilis. International Journal of Biological Macromolecules, 2021; 180: 677-683. (IF: 8.025)
7. Chen, M.R; Kuhle, B.*; Diedrich, J.; Liu, Z.; Moresco, J.; Yates, J.; Pan, T.; Yang, X.L.* Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation. Nucleic Acids Research, 2020; 48: 6445-6457. (IF: 16.971)
8. Chen, M.R.#; Gai, Z.Q#; Okada, C.; Ye, Y.X.; Yu, J.; Yao, M* FlexibleNAD+ Binding in deoxyhypusine synthase reflects the dynamic hypusine modification of translation factor IF5A. International Journal of Molecular Sciences, 2020; 21:5509. (IF: 5.923)
9. Ye, Y.X.#; Chen, M.R.#; Kato, K.; Yao, M.* The pH-dependent conformational change of eukaryotic translation initiation factor 5: Insights into partner-binding manner, Biochemical and Biophysical Research Communications, 2019; 519: 186-191. (IF: 2.985)
10. Chen, M.R.; Kato, K.; Kubo, Y.; Tanaka, Y.; Liu, Y.C.; Long, F.; Whitman, WB.; Lill, P.; Gatsogiannis, C.; Raunser, S.; Shimizu, N.; Shinoda, A.; Nakamura, A.; Tanaka, I.; Yao, M.* Structural basis for tRNA-dependent cysteine biosynthesis. Nature Communications, 2017; 8: 1521. (IF: 12.353)

肖易倍教授团队
指导研究生：
2021级硕士 郭丽洁（国家奖学金） 黄平平（国家奖学金）
2022级硕士 闫朴睿 隋嘉杰
2023级硕士 费文颖 赵洪泽 陈健宇 杨盼