(1)靶向Hsp90-Cdc37-激酶相关系统first in class小分子抑制剂的发现与研究
(2) 靶向丝/苏氨酸蛋白磷酸酶first in class小分子调控剂的发现与研究

1.Hua, L.; Zhang, Q.(共一); Zhu, X.; Wang, R.*; You, Q.*; Wang, L.*, Beyond Proteolysis-Targeting Chimeric Molecules: Designing Heterobifunctional Molecules Based on Functional Effectors. J. Med. Chem. 2022, 65 (12), 8091-8112. (IF: 7.446)
2.Wu, X.; Zhang, Q.(共一); Guo, Y.; Zhang, H.; Guo, X.*; You, Q.*; Wang, L.*, Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein-Protein Interactions: An Update. Antioxidants (Basel) 2022, 11 (4). (IF: 6.313)
3.Wang, L.; Zhang, Q.(共一); You, Q.*, Targeting the HSP90-CDC37-kinase chaperone cycle: A promising therapeutic strategy for cancer. Med. Res. Rev. 2022, 42 (1), 156-182. (IF: 12.944)
4.Zhang, Q.; Wu, X.; Zhou, J.; Zhang, L.; Xu, X.; Zhang, L.*; You, Q.*; Wang, L.*, Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core. Eur. J. Med. Chem. 2021, 210, 112959. (IF: 5.572)
5.Zhang, Q.; Fan, Z.; Zhang, L.; You, Q.*; Wang, L.*, Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer. J. Med. Chem. 2021, 64 (13), 8916-8938. (IF: 7.446)