(1) 阿尔茨海默病早期诊断和治疗一体化探针研究
(2) 癌症诊断药物研究
(3) 小分子药物工艺研发与产业化

1、科研项目
（1）江苏省自然科学基金项目，BK20191320，基于Aβ寡聚体的近红外小分子探针库构建及其阿尔茨海默病早期诊断的研究，2019/07- 2022/06，10万元，在研主持。
（2）国家自然科学基金青年面上项目，81102317，基于缺氧信号通路HIF-1a的实体瘤靶向药物设计、合成与生物活性研究、2012/01-2014/12、19万元、已结题、主持。
（3）省产学研前瞻性项目，Y162002，高端磷脂类药用辅料的生产工艺和质量标准研发，2016/01-2018/12，15万，已结题，主持
（4）国家自然科学基金重点项目，Y121048-3、应用化学和生物信息学技术设计具有Nrf2-Keap1“蛋白-蛋白”相互调控作用的类天然产物研究、2013/01-2017/12、280万元、已结题、参加。

1.Jian Yang, Fantian Zeng, Xiaofang Li, Chongzhao Ran,Yungen Xu * and Yuyan Li*, Highly specific detection of Ab oligomers in earlyAlzheimer’s disease by a near-infrared fluorescentprobe with a ‘‘V-shaped’’ spatial conformation, Chem. Commun., 56(2020), 583--586（IF 6.29）
2.Tianbai Shuai, Yizhou Zhou, Guoqiang Shao, Rui Yang, Letian Wang, Jinglin Wang, Jie Sun, Longfei Ren, Jintao Wang, Yan Liao, Mian Wei, Qingxiang Xu,* Yuyan Li,* and Li Zhao*, Bimodal Molecule as NIR-CT Contrast Agent for Hepatoma SpecificImaging，Anal. Chem. 92(2020): 1138−1146（IF 6.38）
3.Fantian Zeng, Jian Yang , Xiaofang Lia , Kewen Peng , Chongzhao Ran, Yungen Xu⁎ , Yuyan Li,* Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers，Bio. Med. Chem. 28 (2020) 115559（IF3.64）
4.Wen-Jun Xue, Ming-Tao Li, Lin Chen, Li-Ping Sun*, &Yu-Yan Li**, Recent developments and advances of FGFRas a potential target in cancer，Future Med. Chem，2018, 10(17), 2109–2126（IF 3.58）
5.Hongwu Liu, Jianwei Wu , Ying Ge, Aibo Li , Jia Lia, Zhengshi Liu , Yungen Xu, Qingxiang Xu*,Yuyan Li*，Novel aromatic sulfonyl naphthalene-based boronates as 20Sproteasome inhibitors , Bioorganic & Medicinal Chemistry 26 (2018) 1050–1061（IF 2.88）
6.Yuyan Li, Jian Yang, Hongwu Liu, Jing Yang, Lei Du,Haiwei Feng, Yanli Tian, Jianqin Cao and Chongzhao Ran*，Tuning Stereo-hindrance of Curcumin Scaffold for Selective Imaging of Soluble Forms of Amyloid Beta Species， Chemical Science, 8 (2017), 7710 – 7717.（IF9.20）
7.Ying Ge, Aibo Li, Jianwei Wu, Haiwei Feng , Letian Wang , Hongwu Liu ,Yungen Xu, Qingxiang Xu ***, Li Zhao **, Yuyan Li *, Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors, European Journal of Medicinal Chemistry, 128(2017): 180-191.（IF 4.52）
8.Hongwu Liu, Jian Yang​‌, Letian Wang​‌, Yungen Xu, Siyuan Zhang​‌, JieLv, Chongzhao Ran, Yuyan Li​‌*, Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes，Future Medicinal Chemistry， 9(2017), 179-198.（IF 3.58）
9.Yanli Tian，Xueli Zhang，Yuyan Li，Timothy M. Shoup，Xin Teng，David R. Elmaleh，Anna Moore*，Chongzhao Ran*，Crown ethers attenuate aggregation of Amyloid beta of Alzheimer’sdisease，Chem.Comm.，50（2014）：15792-15795。（IF6.38）
10.Ye-Xiang Su, Ya-Hui Deng, Ting-Ting Ma, Yu-Yan Li* and Li-Ping Sun*.“On water”direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives[J]. Green Chem., 14(2012), 1979（IF 6.32）