(1) 生物大分子载体研究
(2) 原位凝胶载药技术开发
(3) 长效缓释制剂研发与产业化

1、科研项目
（1）国家自然科学基金委员会，青年项目，81402859，基于核酸适配体识别的肿瘤靶向自组装DNA纳米笼载药系统的研究，2015-01-01 至 2017-12-31，23万元，结题，主持；
（2）江苏省科技厅，江苏省自然科学基金青年基金项目，BK20130663，复乳前体自组装系统的构建及其促吸收机制的研究，2013-07 至 2016-06，20万元，已结题，主持；
（3）国家新药创制重大专项子课题，基于生物合成途径改造的关键技术和HXSW-101临床前研究，2017-01至2021-12，15万元，已结题，参与。

1.Pan, X.H.; Pei, X.C.; Huang, H.Q.; Su, N.; Wu, Z.H.; Wu,Z.H.*; Qi, X.L.* One-in-One Individually Package and Delivery of CRISPR/Cas9 Ribonucleoprotein Using Apoferritin Nanoshell for Genome Editing. J Control Release. 2021;337:686-97. (IF: 9.776)
2.Han, X.; Xu, X.; Wu, Z.H.; Wu, Z.H.*; Qi, X.L.* Synchronous Conjugation of i-motif DNA and Therapeutic siRNA on the Vertexes of Tetrahedral DNA Nanocages for Efficient Gene Silence. Acta Pharm Sin B. 2021;11:3286-96. (IF: 11.413)
3.Veroniaina, H.; Wu, Z.H.*; Qi, X.L.* Innate tumor-targeted nanozyme to relieve tumor hypoxia and provide MRI contrast agent for cancer theranostics. J Adv Res. 2021;33:201-13. (IF: 10.479)
4.Pei, X.C.; Pan, X.H.; Xu X.Y.; Xu, X.; Huang, H.Q.; Wu, Z.H.*; Qi, X.L.* 4T1 cell membrane fragments reunited PAMAM polymer disguising as tumor cell clusters for tumor homotypic targeting and anti-metastasis treatment. Biomater Sci. 2021; 9:1325-33. (IF: 6.183)
5.Huang, H.Q.; Sha K.; Veroniaina H.; Wu, Z.H.; Wu, Z.H.*; Qi, X.L.* Ca2+ participating self-assembly of an apoferritin nanostructure for nucleic acid drug delivery. Nanoscale. 2020;12:7347-57. (IF: 7.79)
6.Huang, H.Q.; Yuan S.R.;Ma Z.; Ji, P.; Ma X.N.; Wu, Z.H.*; Qi, X.L.* Genetic recombination of poly(L-lysine) functionalized apoferritin nanocages that resemble viral capsid nanometer-sized platforms for gene therapy. Biomater Sci. 2020;8:1759-70. (IF: 6.183)
7.Ji, P.; Wang L.; Chen, Y.W.; Wang, S.Q.; Wu, Z.H.*; Qi, X.L.* Hyaluronic acid hydrophilic surficial rehabilitative curcumin nanocrystals for targeted breast cancer treatment with prolonged biodistribution. Biomater Sci. 2020;8:462-72. (IF: 6.183)
8.Ji, Peng.; Huang, H.Q.; Yuan, S.R.; Wang, L.; Wang, S.Q.; Chen, Y.W.; Feng, N.; Veroniaina H.; Wu, Z.H.; Wu, Z.H.*; Qi, X.L.* ROS-mediated apoptosis and anticancer effect achieved by artesunate and auxiliary Fe(II) released from ferriferous oxide-containing recombinant apoferritin. Adv Healthc Mater. 2019;8:e1900911. (IF: 9.933)
9.Wu, Ming.; Chen, J.J.; Veroniaina H.; Mukhopadhyay S,; Wu, Z.H.; Wu, Z.H.*; Qi, X.L.* Pea-like Nanocabins enable autonomous cruise and step-by-step drug pushing for deep tumor inhibition.Nanomedicine. 2019;18:122-34. (IF: 6.5)
10.Han, Xiu.; Jiang Y.J.; Li S.Y.; Zhang Y.; Ma X.N.;Wu, Z.H.; Wu, Z.H.*; Qi, X.L.* Aptamer Multivalent Modified Tetrahedral DNA Nanocage Demonstrated Highly Selectivity and Safety for Anti-tumor Therapy. Nanoscale. 2018;11:339-47. (IF: 7.79)