(1) 难溶性药物共晶制剂研究
(2) 药物共结晶及药物开发中的质量研究
(3) 药物固态化学和多晶型筛选

1、科研项目
（1）国家自然科学基金委员会, 国家自然科学基金青年项目, No. 22108313, 2022-01至2024-12, 30万，在研，主持
（2）江苏省科技厅，江苏省自然科学基金青年基金项目，BK 20200576，2021-07至2023-06，24万，在研，主持。
（3）中央高校基本科研业务，重点项目，No 2632022ZD16，2022-01至2023-12， 20万，在研，主持。
（4）中央高校基本科研业务，培育项目，No. 2632020PY04，2020-01至2021-12， 8万，已结题，主持。

1. Guo M, Sun X, Zhang S, Cai T. Modulation of Solid-State Chemical Stability of Gabapentin by Pyridinecarboxylic Acid. Pharmaceutical Research. 2022. (IF: 4.914)
2. Chen J1, Guo M1, Fan R, Peng Y, Cai T. Impact of Bile Salt on Solution-Mediated Phase Transformation of Pharmaceutical Cocrystals: The Importance of Coformer Release Kinetics. Chemical Engineering Journal. 2022; 435: 134928. (IF: 16.744)
3. Guo,M, Sun, X, Chen, J, Cai, T.* Pharmaceutical Cocrystals: A Review of Preparations, Physicochemical Properties and Applications. Acta Pharmaceutica Sinica B 2021, 11，2537-2564 (IF: 11.614)
4. Huang S, Xu J, Peng Y, Guo M*, Cai T. * Facile Tuning of the Photoluminescence and Dissolution Properties of Phloretin through Cocrystallization. Cryst. Growth Des. 2019; 19 (12): 6837-6844. (IF: 4.089)
5. Guo M, Wang K, Qiao N, Yardley V, Li M. Investigating Permeation Behavior of Flufenamic Acid Cocrystals Using a Dissolution and Permeation System. Molecular Pharmaceutics. 2018; 15 (9): 4257-4272. (IF: 4.3)
6. Guo M, Wang K, Qiao N, Fábián L, Sadiq G, Li M. Insight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: From Single Crystal to Powder Dissolution. Molecular Pharmaceutics. 2017; 14 (12): 4583-4596. (IF: 4.4)
7. Guo M, Wang K, Hamill N, Lorimer K, Li M. Investigating the Influence of Polymers on Supersaturated Flufenamic Acid Cocrystal Solutions. Molecular Pharmaceutics. 2016; 13 (9): 3292-3307. (IF: 4.6)