(1) 新金属配合物药物
(2) 病理结晶与生物矿化
(3) 免疫稳态与调控

1、科研项目
（1）国家自然科学基金青年项目，81801814，工程化细胞外囊泡介导铂类前药-免疫检查点阻断剂纳米粒逆转顺铂耐药肿瘤的研究，2019-01 至 2021-12，21万元，结题，主持

1. Ling, X.; Gong, D.; Shi, W.; Xu, Z.; Han, W.; Lan, G.; Li, Y.; Qin, W.; Lin, W. Nanoscale Metal-Organic Layers Detect Mitochondrial Dysregulation and Chemoresistance via Ratiometric Sensing of Glutathione and pH. Journal of the American Chemical Society 2021. DOI: 10.1021/jacs.0c11764. (IF = 14.612)
2. Ling, X.; Han, W.; Jiang, X.; Chen, X.; Rodriguez, M.; Zhu, P.; Wu, T.; Lin, W. Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy. Biomaterials 2021. DOI: 10.1016/j.biomaterials.2021.120690. (IF = 10.317)
3. Ling, X.; Jiang, X.; Li, Y.; Han, W.; Rodriguez, M.; Xu, Z.; Lin, W. Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity. ACS Nano 2020. DOI: 10.1021/acsnano.0c07132. (IF = 14.588)
4. Ling, X.; Tu, J.; Wang, J.; Shajii, A.; Kong, N.; Feng, C.; Zhang, Y.; Yu, M.; Xie, T.; Bharwani, Z.; Aljaeid, B. M.; Shi, B.; Tao, W.; Farokhzad, O. C. Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy. ACS Nano 2019, 13, (1), 357-370. (IF = 14.588)
5. Xiong, F.; Ling, X. (Co-first); Chen, X.; Chen, J.; Tan, J.; Cao, W.; Ge, L.; Ma, M.; Wu, J. Pursuing Specific Chemotherapy of Orthotopic Breast Cancer with Lung Metastasis from Docking Nanoparticles Driven by Bioinspired Exosomes. Nano Letters 2019, 19 (5), 3256-3266. (IF = 11.238)
6. Chen, X.; Ling, X. (Co-first); Zhao, L.; Xiong, F.; Hollett, G.; Kang, Y.; Barrett, A.; Wu, J. Biomimetic shells endow sub-50 nm nanoparticles with ultrahigh paclitaxel payloads for specific and robust chemotherapy. ACS Applied Materials & Interfaces 2018, 10 (40), 33976-33985. (IF = 8.758)
7. Ling, X.; Chen, X.; Riddell, I. A.; Tao, W.; Wang, J.; Hollett, G.; Lippard, S. J.; Farokhzad, O. C.; Shi, J.; Wu, J. Glutathione-scavenging poly(disulfide amide) nanoparticles for the effective delivery of Pt(IV) prodrugs and reversal of cisplatin resistance. Nano Letters 2018, 18 (7), 4618-4625. (IF = 11.238)