(1) 药代动力学建模仿真
(2) 阿尔茨海默病新机制新靶标发现与确证

1、科研项目
（1）国家自然科学基金委员会，青年科学基金项目，81903703，LMTK1调控核内体转运介导阿尔茨海默病神经元Reserve机制研究，2020-01-01 至 2022-12-31，21万元，在研，主持

1.Zhao Huimin, Wei Jie, Du Yanan, Chen Peipei, Liu Xiaoquan*, Liu Haochen*; Improved cognitive impairments by silencing DMP1 via enhancing the proliferation of neural progenitor cell in Alzheimer-like mice, Aging cell, 2022-03-22. (IF=9.304)
2.Liu Haochen, Zhang Yixuan, Zhao Huimin, Du Yanan, Liu Xiaoquan*; The heterogeneity among subgroups of haplogroup J influencing Alzheimer’s disease risk, J ADV RES, 2021, 33(1):117-126. (IF=10.479)
3.Zhang Yixuan, Wang Jiali, Liu Xiaoquan*, Liu Haochen*; Exploring the role of RALYL in Alzheimer's disease reserve by network-based approaches, Alzheimers Res Ther, 2020, 12(1):165. (IF=6.982)
4.Liu Haochen, Zhang Hong, Zhang Yixuan, Xu Sheng, Zhao Hhuimin, He Hua*, Liu Xiaoquan*; Modeling mtDNA hypermethylation vicious circle mediating Abeta-induced endothelial damage memory in HCMEC/D3 cell, Aging, 2020, 12(18):18343-18362. (IF=5.682)
5.Liu Haochen, Zhang Yixuan, Zhang Huimin, Xu Sheng, Zhao Huimin, Liu Xiaoquan*; Abeta-Induced Damage Memory in hCMEC/D3 Cells Mediated by Sirtuin-1, Int J Mol Sci, 2020, 21(21):8226. (IF=5.923)
6.Liu Haochen, Zhou Xiaoting, Zheng Yunsi, He Hua*, Liu Xiaoquan*; PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats, Acta Pharmacol Sin, 2020, 41(5):719-728. (IF=6.15)
7.Wang Jiali, Zhang Yixuan, Liu Xiaoquan*, Liu Haochen*; Optimizing Adaptive Therapy Based on the Reachability to Tumor Resistant Subpopulation, Cancers, 2021, 13(21):5262. (IF=6.639)
8.Wang Jiali, Zhang Yixuan, Liu Xiaoquan*, Liu Haochen*; Is the Fixed Periodic Treatment Effective for the Tumor System without Complete Information?, Cancer Manag. Res., 2021, 13(1):8915-8928. (IF=3.989)

研究团队
柳晓泉 教授
何华 副教授
刘昊晨 讲师
博士研究生
赵慧敏
罗安琪
硕士研究生
陈佩佩、魏杰、骆诗峥、孔倩倩、穆峣、李玥、赖思娴、赵一馨、刘育言