(1) 口服药物递送系统开发及其免疫调控研究；
(2) 肿瘤/炎症性疾病免疫调控。

1、科研项目
（1）国家自然科学基金面上项目，2025/01至2028/12，进行中，主持
（2）国家自然科学基金高层次青年人才项目，2024/01至2026/12，进行中，主持
2、代表性科研成果
（1）研发结肠滞留性菊粉水凝胶，调控肠道菌群及代谢物，增强免疫检查点抑制剂抗体疗效，并降低其肠道毒性。
（2）研发菊粉水凝胶/过敏原蛋白质口服递送系统，提高蛋白质药物在病灶处滞留，同时调控回肠菌群及其代谢物，诱导免疫耐受环境，实现食物过敏长效治疗。

1. K Han^†, F Xie^†, JJ Moon^*, et al., Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy, Nat. Mater. 2024, doi.org/10.1038/s41563-024-01909-w.
2. K Han, JJ Moon^*, et al., Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel, Nat. Biomed. Eng. 2021, 5: 1377.
3. K Han^†, YS Cho^†, JJ Moon^*, Antibiotic nanoparticles boost antitumor immunity, Nat. Biotechnol. 2024, 42: 1187.
4. K Han^†,*, J Xu^†, F Xie^†, JJ Moon^*, et al., Engineering strategies to modulate the gut microbiome and immune system, J. Immunol. 2024, 212: 208.
5. YS Cho^†, K Han^†, JJ Moon^*, et al., Novel strategies for modulating the gut microbiome for cancer therapy, Adv. Drug Deliver. Rev. 2024, 210: 115332.
6. ZY Ma, K Han^*, HY Han^*, et al., Precisely striking tumor without adjacent normal tissue damage via mitochondria-templated accumulation, ACS Nano 2018, 12: 6252.
7. XX Dai^†, K Han^†,*, HY Han^*, et al., A chimeric peptide logic gate for orthogonal stimuli-triggered precise tumor therapy, Adv. Funct. Mater. 2018, 28: 1804609.
8. K Han, HY Han^*, et al., Tumor-triggered geometrical shape switch of chimeric peptide for enhanced in vivo tumor internalization and photodynamic therapy, ACS Nano 2017, 11: 3178.

研究团队
博士研究生：吴宛涛（2023级），侯加珍（2024级）
硕士研究生：凌超群（2023级）, 孙宏磊（2024级）, 田允（2024级）, 吴欣（2024级）