抗肿瘤创新药物研究

（1）National Natural Science Foundation of China, Youths Science Foundation of China, 82204188, Design, synthesis and anti-tumor activity of a novel TRK-targeting small molecule targeting xDFG mutation resistance, 2023-01-01 to 2025-12-31.
（2）China Postdoctoral Science Foundation, Postdoctoral General Program, 2022M713482, Design and synthesis of novel TRK-targeting small molecules and their anti-drug resistance activity, 2022-07-01 to 2025-06-30, 80, 000.

1. Huajian Zhu; Yuchen Tan; Chen He; Yang Liu; Yiping Duan; Wenjian Zhu; Tiandong Zheng; Dahong Li; Jinyi Xu; Dong-Hua Yang; Zhe-Sheng Chen; Shengtao Xu ; Discovery of a Novel Vascular Disrupting Agent Inhibiting Tubulin Polymerization and HDACs with Potent Antitumor Effects, J Med Chem. 2022, 65(16): 1118. (IF: 8.039)
2.Zhu, H.J; Lu, L.X.; Zhu, W.J.; Tan, Y.C.; Duan, Y.P.; Liu, J.*; Ye, W.C.; Zhu, Z.Y.; Xu, J.Y.*; Xu, S.T.; Design and synthesis of NAD(P)H: Quinone oxidoreductase (NQO1)-activated prodrugs of 23-hydroxybetulinic acid with enhanced antitumor properties. Eur J Med Chem. 2022; 240: 114575. (IF: 7.088)
3.Zhu, H.J; Li, W.L.; Shuai, W.; Liu Y.; Yang, L.M; Tan, Y.C.; Zheng, T.D.; Yao, H.; Xu, J.Y; Zhu, Z.Y.; Yang, D.H.; Chen, Z.S.; Xu, S.T.; Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities. Eur J Med Chem. 2021; 216: 113316. (IF: 7.088)
4.Zhu, H.J; Sun, H.H.; Liu, Y.; Duan, Y.P.; Liu, J.; Yang, X.; Li, W.L.; Qin, S.; Xu, S.T.; Zhu, Z.Y.; Xu, J.Y.; Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem. 2020, 207: 112716. (IF: 6.514)

徐进宜 教授
徐盛涛副研究员
姚鸿副研究员